Syrjänen S, Syrjänen K, Yli-Urpo A
Acta Odontol Scand. 1984 Dec;42(6):321-5. doi: 10.3109/00016358409033610.
Transferrin (TF) is a metal-binding protein that has been detected in human mucosal tissues. Positive TF reactivity has been related to iron transport, epithelial keratinization, and the non-specific defense system of mucosal membranes. An immunoperoxidase staining technique was used to study the distribution of TF in buccal mucosa adjacent to different metallic restorations (62 cases) to assess the nature of tissue changes possibly attributable to dental materials. The transferrin reactivity in the oral epithelium of 10 patients with galvanic symptoms was also determined. The results showed an obvious shift in TF reactivity from weak to strong in patients with complete dentures and in those with galvanic symptoms when compared with controls. The results are discussed in terms of epithelial cell proliferation and keratinization and of the role of TF in chelating free metallic ions.
转铁蛋白（TF）是一种金属结合蛋白，已在人体黏膜组织中被检测到。TF阳性反应与铁运输、上皮角质化以及黏膜的非特异性防御系统有关。采用免疫过氧化物酶染色技术研究了不同金属修复体相邻颊黏膜中TF的分布情况（62例），以评估可能归因于牙科材料的组织变化的性质。还测定了10例有电流刺激症状患者口腔上皮中的转铁蛋白反应性。结果显示，与对照组相比，全口义齿患者和有电流刺激症状的患者TF反应性明显从弱变强。从上皮细胞增殖和角质化以及TF在螯合游离金属离子中的作用方面对结果进行了讨论。
