Delacoux E, Moreau Y, Godefroy A, Evstigneeff T
J Fr Ophtalmol. 1978 Mar;1(3):191-6.
In order to define the means of prevention of the ocular toxicity of ethambutol (EMB), 72 patients under treatment with EMB-INH-Rifampicin combination were subjected to systematic analysis of plasma, blood and urinary zinc levels together with a full ophthalmic examination. Comparison of the results from 12 patients sustaining ocular damage at the time of treatment with the results of 60 others: 1) demonstrates the existence of a correlation between plasma zinc levels before treatment and the probability of ocular damage from EMB (high risk for zinc is less than 0.70 mg/l - almost no risk for zinc greater than 1 mg/l); 2) confirms that dyschromatopsia is one of the first signs of ocular damage through EMB and thus constitutes an alarm signal; 3) suggests that the ocular toxicity of EMB might appear in the retina before the optic nerve.
为了确定预防乙胺丁醇（EMB）眼部毒性的方法，对72例接受EMB-异烟肼-利福平联合治疗的患者进行了血浆、血液和尿液锌水平的系统分析，并进行了全面的眼科检查。将12例治疗时出现眼部损害的患者的结果与另外60例患者的结果进行比较：1）表明治疗前血浆锌水平与EMB所致眼部损害的可能性之间存在相关性（锌水平低于0.70mg/L为高风险——锌水平高于1mg/L几乎无风险）；2）证实色觉障碍是EMB所致眼部损害的早期体征之一，因此构成一个警示信号；3）提示EMB的眼部毒性可能在视神经之前先出现在视网膜。
