Matsubara H, Kitahara M, Takeda T, Yazawa Y
Acta Otolaryngol Suppl. 1984;419:115-22.
The glycerol effect for endolymphatic hydrops is well known for an improvement in pure tone threshold three hours after glycerol administration. However, long-term effects of glycerol, i.e., longer than three hours after administration, are unknown. In this study, audiometric tests were administered during 10 hours following glycerol administration in order to determine the long-term effects of glycerol in cases of Meniere's disease, sudden deafness, and normal subjects. The following results were obtained; 1) The long-term effects of glycerol in the pure tone threshold were observed only in cases of Meniere's disease and were classified into the following four types: "descending type", "descending and ascending type", "ascending type" and "unchanged type". 2) The long-term effects, including rebound phenomenon, on hearing ability did not appear in cases of sudden deafness and normal subjects. 3) About 50% of patients with Meniere's disease showed rebound phenomenon on hearing ability and it was considered to be specific for Meniere's disease.
甘油对内淋巴积水的作用以甘油给药三小时后纯音阈值改善而闻名。然而，甘油的长期作用，即给药三小时后更长时间的作用尚不清楚。在本研究中，在甘油给药后的10小时内进行听力测试，以确定甘油对梅尼埃病、突发性聋患者及正常受试者的长期作用。得到以下结果：1）甘油对纯音阈值的长期作用仅在梅尼埃病患者中观察到，并分为以下四种类型：“下降型”、“下降及上升型”、“上升型”和“不变型”。2）突发性聋患者及正常受试者未出现包括反弹现象在内的对听力的长期作用。3）约50%的梅尼埃病患者出现听力反弹现象，这被认为是梅尼埃病的特异性表现。
