Jennings G L, Korner P I, Laufer E, Esler M D, Burton D, Bruce A
J Hypertens Suppl. 1984 Dec;2(3):S217-9.
Long-term therapy (1.5-27 years, average 7.5 years) was ceased in 11 patients with essential hypertension. The return of supine hypertension during the ensuing 10 weeks was slow and incomplete, contrasting with previous studies when blood pressure (BP) had been lowered for shorter periods. After prolonged therapy in these patients, non-autonomic total peripheral resistance index (TPRI) was near normal, but left ventricular mass index (LVMI) was still high in six of the 11 patients. The latter was directly related to duration of effective treatment of BP and to BP when therapy was stopped. These findings may indicate that with antihypertensive therapy, structural changes in the peripheral vasculature regress more quickly than cardiac hypertrophy.
11例原发性高血压患者停止长期治疗（1.5 - 27年，平均7.5年）。在随后的10周内，仰卧位高血压的恢复缓慢且不完全，这与之前血压降低较短时间的研究形成对比。在这些患者经过长期治疗后，非自主性总外周阻力指数（TPRI）接近正常，但11例患者中有6例左心室质量指数（LVMI）仍然很高。后者与血压有效治疗的持续时间以及治疗停止时的血压直接相关。这些发现可能表明，在抗高血压治疗中，外周血管系统的结构变化比心脏肥大消退得更快。
