Celestino D, Orofino A
J Laryngol Otol. 1978 Jun;92(6):467-76. doi: 10.1017/s0022215100085637.
The effect of osmotic treatment on cases with fluctuating sensorineural hearing loss other than Menière's disease is described in this paper. Complete normalization of the hearing threshold has been obtained in eight patients suffering from cochlear hydrops (one case), sensorineural concussion deafness (five cases), temporary noise threshold shift (one case), sudden deafness (two cases). Relief of tinnitus has been observed in a case of post-stapedectomy deafness. The audiometric pattern of end organ disease in a case of cohlear otosclerosis showed a change into a classical otosclerosis audiograph after glycerol administration. The action of osmotic drugs on the inner ear is though to be twofold, i.e. reabsorbing hydrops and normalizing rheological alterations. Therefore, an osmotic treatment is indicated for menieric and non-menieric hydrops and for microcirculatory impairment of the labyrinth. On the basis of these statements the glycerol test for the diagnosis of Menière's disease is called into doubt as not being absolutely specific.
本文描述了渗透性治疗对除梅尼埃病外的波动性感音神经性听力损失病例的疗效。8例患有耳蜗积水（1例）、感音神经性震荡性耳聋（5例）、暂时性噪声阈值偏移（1例）、突发性耳聋（2例）的患者听力阈值已完全恢复正常。在1例镫骨切除术后耳聋病例中观察到耳鸣减轻。1例耳蜗性耳硬化症终器疾病的听力图在给予甘油后显示转变为典型的耳硬化症听力图。渗透性药物对内耳的作用被认为是双重的，即吸收积水和使流变学改变正常化。因此，渗透性治疗适用于梅尼埃病和非梅尼埃病性积水以及迷路的微循环障碍。基于这些陈述，用于诊断梅尼埃病的甘油试验因其并非绝对特异性而受到质疑。
