阿尔茨海默病与组织相容性抗原之间不存在关联。

Lack of association between Alzheimer's disease and histocompatibility antigens.

作者信息

Reisner E, Heyman A, Weinberg T, Dawson D, Ciftan E

出版信息

Tissue Antigens. 1983 Jan;21(1):31-4. doi: 10.1111/j.1399-0039.1983.tb00368.x.

DOI:10.1111/j.1399-0039.1983.tb00368.x

Abstract

The present report describes the distribution of histocompatibility antigens in 52 patients with Alzheimer's disease. No significant associations were observed between this illness and particular HLA types before or after statistical correction for multiple comparisons. These findings are discussed in terms of the difficulties inherent in the clinical diagnosis of Alzheimer's disease and with regard to the choice of suitable control populations.

摘要

本报告描述了52例阿尔茨海默病患者组织相容性抗原的分布情况。在对多重比较进行统计校正前后，均未观察到该疾病与特定人类白细胞抗原（HLA）类型之间存在显著关联。本文将结合阿尔茨海默病临床诊断中固有的困难以及合适对照人群的选择来讨论这些发现。