阿尔茨海默病中的人类白细胞抗原

HLA antigens in Alzheimer's disease.

作者信息

Sulkava R, Koskimies S, Wikström J, Palo J

出版信息

Tissue Antigens. 1980 Aug;16(2):191-4. doi: 10.1111/j.1399-0039.1980.tb00602.x.

DOI:10.1111/j.1399-0039.1980.tb00602.x

Abstract

The histocompatibility antigens of the A, B and C loci were typed for 32 patients with Alzheimer's disease and 35 controls of the same age. The results were also compared to the distribution of HLA antigens in a series of 900 healthy blood donors. No statistically significant differences were found between the Alzheimer patients and the controls. HLA--Cw1 was found significantly less frequently in the group comprising the patients with Alzheimer's disease and their controls together, than in the younger blood group. This leads us to suggest that an age-matched control group may be needed, at least when the patients are elderly.

摘要

对32例阿尔茨海默病患者和35名同龄对照者进行了A、B和C位点的组织相容性抗原分型。结果还与900名健康献血者的HLA抗原分布进行了比较。在阿尔茨海默病患者和对照者之间未发现统计学上的显著差异。在包括阿尔茨海默病患者及其对照者在内的组中，HLA - Cw1的出现频率明显低于较年轻的血型组。这使我们认为，至少当患者为老年人时，可能需要一个年龄匹配的对照组。