L-5-羟色氨酸用于麦角酸二乙酰胺所致精神病。

L-5-hydroxytryptophan for LSD-induced psychosis.

作者信息

Abraham H D

出版信息

Am J Psychiatry. 1983 Apr;140(4):456-8. doi: 10.1176/ajp.140.4.456.

DOI:10.1176/ajp.140.4.456

Abstract

The serotonin precursor L-5-hydroxytryptophan reversed the symptoms of a 23-year-old man suffering from LSD-induced psychosis who participated in a randomized, double-blind crossover study of the drug and a placebo. This finding is compatible with the speculation that some LSD-induced psychotic disorders may be caused by a relative deficiency of CNS serotonin.

摘要

血清素前体L-5-羟色氨酸逆转了一名23岁患有麦角酸二乙酰胺（LSD）所致精神病男性的症状，该男子参与了一项关于该药物和安慰剂的随机、双盲交叉研究。这一发现与某些LSD所致精神障碍可能由中枢神经系统血清素相对缺乏引起的推测相符。