Goldstein B G, Buettner H
Arch Ophthalmol. 1983 May;101(5):774-7. doi: 10.1001/archopht.1983.01040010774016.
A patient had a 12-year history of relapsing disseminated histoplasmosis. None of the characteristic lesions of the presumed ocular histoplasmosis syndrome were present in either eye. Ocular involvement began as a peripheral focal retinitis associated with vitreitis and iritis. Histoplasma capsulatum organisms grew in cultures from aqueous and vitreous and were demonstrated histologically in an iridectomy specimen. Despite intraocular and subconjunctival administration of amphotericin B, intractable pain associated with progressive necrotizing granulomatous iridocyclitis necessitated enucleation. Histoplasma capsulatum organisms were seen extracellularly in the vitreous cavity and both intracellularly and extracellularly in areas of granulomatous inflammation involving the iris, ciliary body (diffusely), and the retina (focally). The choroid was not involved.
一名患者有12年复发性播散性组织胞浆菌病病史。双眼均未出现推测的眼组织胞浆菌病综合征的特征性病变。眼部受累起初表现为与玻璃体炎和虹膜炎相关的周边局灶性视网膜炎。荚膜组织胞浆菌在房水和玻璃体培养物中生长，并在虹膜切除术标本中经组织学证实。尽管眼内和结膜下给予了两性霉素B，但与进行性坏死性肉芽肿性虹膜睫状体炎相关的顽固性疼痛仍需眼球摘除。在玻璃体腔中可见细胞外的荚膜组织胞浆菌，在累及虹膜、睫状体（弥漫性）和视网膜（局灶性）的肉芽肿性炎症区域可见细胞内和细胞外的荚膜组织胞浆菌。脉络膜未受累。
