Toonstra J, Van Der Putte S C, Kalsbeek G L
Dermatologica. 1983;166(3):128-35.
2 middle-aged men are described with slowly progressive papular and nodular lesions, limited to the skin of the back. Clinically and histologically both resembled Crosti's reticulosis ('réticulo-histiocytome du dos de l'adulte'). It was determined by electron microscopic, enzyme cytochemical and immunological studies that the 'histiocyte' component, which was derived from T lymphocytes, consisted of blast-like cells with characteristic multilobated nuclei with nucleoli in marginal position. For this type of lymphoma, which may have been described previously as lymphocytoma cutis or reticulum cell sarcoma, the term 'multilobated cutaneous T cell lymphoma' is proposed. According to its slowly progressive clinical course it may be classified as a malignant lymphoma of low grade malignancy.
描述了2名中年男性,其背部皮肤出现缓慢进展的丘疹和结节性病变。临床和组织学表现均类似于克罗斯蒂网状细胞增多症(“成人背部网状组织细胞瘤”)。通过电子显微镜、酶细胞化学和免疫学研究确定,源自T淋巴细胞的“组织细胞”成分由具有特征性多叶核且核仁位于边缘位置的母细胞样细胞组成。对于这种可能先前被描述为皮肤淋巴细胞瘤或网状细胞肉瘤的淋巴瘤类型,建议使用“多叶性皮肤T细胞淋巴瘤”这一术语。根据其缓慢进展的临床病程,可将其归类为低级别恶性淋巴瘤。