Toss G, Symreng T
Int J Vitam Nutr Res. 1983;53(1):27-31.
The relationship between delayed hypersensitivity and serum levels of 25-hydroxyvitamin D were examined in sixty-three elderly people. After intracutaneous injection of five recall antigens (Candida, mumps, PPD, tricophyton and varidase) nineteen subjects showed no response (anergy), seven showed only a weak reaction (relative anergy), and thirty-seven a normal reaction. In the anergic group mean serum level of 25-hydroxyvitamin D was significantly lower than in the group with normal immunoreactivity. Five subjects with anergy and serum 25-hydroxyvitamin D below 20 nmol/l were treated with oral vitamin D or UV irradiation for two to three months, after which both the serum 25-hydroxyvitamin D levels and the delayed hypersensitivity were normalized. In a non-treated group anergy persisted in seven out of nine patients in a second skin test. We conclude that anergy in the delayed hypersensitivity skin test in humans may in some cases be due to vitamin D deficiency.
在63名老年人中研究了迟发型超敏反应与血清25-羟维生素D水平之间的关系。皮内注射5种回忆抗原（白色念珠菌、腮腺炎、结核菌素、毛癣菌和链激酶）后，19名受试者无反应（无反应性），7名仅表现出微弱反应（相对无反应性），37名反应正常。无反应性组的血清25-羟维生素D平均水平显著低于免疫反应正常组。5名无反应性且血清25-羟维生素D低于20 nmol/l的受试者接受口服维生素D或紫外线照射治疗2至3个月，之后血清25-羟维生素D水平和迟发型超敏反应均恢复正常。在一个未治疗组中，9名患者中有7名在第二次皮肤试验中仍存在无反应性。我们得出结论，人类迟发型超敏反应皮肤试验中的无反应性在某些情况下可能是由于维生素D缺乏所致。
