Stone S H, Traugott U, Raine C S
J Neuroimmunol. 1983 Jun;4(3):187-99. doi: 10.1016/0165-5728(83)90035-8.
Experimental autoimmune (allergic) encephalomyelitis (EAE) was induced in Strain 2 guinea pigs, a strain usually regarded as resistant to EAE. The development of disease in groups of juvenile male or female Strain 2/N guinea pigs was irregular with clinical EAE manifesting only in some groups of females. All animals examined morphologically (12 females and 9 males), between 3 and 18 months postinoculation, showed extensive changes in the central nervous system, although 12 of these had displayed no neurologic signs. This silent central nervous system disease, reminiscent of similar phenomena in man, indicates that Strain 2/N is fully competent immunologically at the level of the target organ.
实验性自身免疫性（过敏性）脑脊髓炎（EAE）在2系豚鼠中诱发，该品系通常被认为对EAE有抵抗力。幼年雄性或雌性2/N系豚鼠组中疾病的发展并不规律，临床EAE仅在部分雌性豚鼠组中出现。在接种后3至18个月对所有动物（12只雌性和9只雄性）进行形态学检查，结果显示中枢神经系统有广泛变化，尽管其中12只未表现出神经体征。这种无症状的中枢神经系统疾病，使人联想到人类的类似现象，表明2/N系在靶器官水平上具有完全的免疫能力。
