Salmon H
Thymus. 1983 Mar;5(2):105-13.
Study of the distribution of P+S+ and P-S+ cells in various lymphoid organs of pig revealed that the thymus contains the highest proportion of P+S+ cells (75.5 +/- 4.2%). In vivo treatment of neonatal piglets with cortisone: (i) Reduced both the area of the thymic cortex even more than the medulla and the P+S+ cells more than the P-S+ cells, suggesting the respective origin of these two populations in these two tissue compartments. Moreover, cortisone-resistant thymocytes responded better than the control untreated pig thymocytes to Con A and PHA stimulation. (ii) Reduced the number of P+S+ cells in peripheral organs. Separation of adult thymocytes into P+S+ and P-S+ cell fractions showed that P-S+ cells responded better than P+S+ to Con A and PHA stimulation. Cortisone-resistant thymocytes and P-S+ cells showed the same cell size distribution and both are enriched in medium sized cells. Thus, it is concluded that the property of rosette formation with pig red blood cells allows the identification of two subsets of pig thymocytes with different biological properties and thymic locations, which by analogy with other species may prove to have different patterns of emigration to peripheral organs.
对猪的各种淋巴器官中P+S+和P-S+细胞分布的研究表明，胸腺中P+S+细胞的比例最高（75.5±4.2%）。用可的松对新生仔猪进行体内处理：（i）使胸腺皮质的面积减少幅度甚至超过髓质，使P+S+细胞减少幅度超过P-S+细胞，这表明这两种细胞群体分别起源于这两个组织区域。此外，抗可的松胸腺细胞对刀豆球蛋白A和植物血凝素刺激的反应比未处理的对照猪胸腺细胞更好。（ii）减少外周器官中P+S+细胞的数量。将成年胸腺细胞分离为P+S+和P-S+细胞组分表明，P-S+细胞对刀豆球蛋白A和植物血凝素刺激的反应比P+S+细胞更好。抗可的松胸腺细胞和P-S+细胞显示出相同的细胞大小分布，且两者都富含中等大小的细胞。因此，可以得出结论，与猪红细胞形成玫瑰花结的特性允许识别具有不同生物学特性和胸腺位置的猪胸腺细胞的两个亚群，类比其他物种，这两个亚群可能具有不同的向外周器官迁移的模式。
