Raimondi A J, Tomita T
Childs Brain. 1983;10(3):193-207. doi: 10.1159/000120114.
Among 341 childhood brain tumors treated at Northwestern University--Children's Memorial Hospital during the years 1967-1980, there were 39 children (11%) who presented during the first year of life. Half of the total number of childhood choroid plexus papillomas, meningeal sarcomas and teratomas we treated occurred in this particular age group. Supratentorial tumors were more common than infratentorial, a rate of 1.8:1. Medulloblastoma and benign astrocytoma were the most common histological types. Hydrocephalus was present in 82% of the children and papilledema in 28%, so that progressive enlargement of head circumference was the most common reason for referral. For the 37 patients who underwent surgical removal or biopsy of the tumor, the 1-month mortality rate was 19% and the 1-, 3- and 5-year survival rates were 46, 30 and 22%, respectively. Whenever tolerated, roentgen therapy was given. Most of the 24 deaths occurred within 6 months of the time of diagnosis. 5 patients (1 each with malignant astrocytoma, medulloblastoma, meningeal sarcoma, and 2 with choroid plexus papilloma) are still alive 5 years later, without neurological or mental deficit, and with no sign of recurrence. There were three exceptions to Collin's rule. Among the 15 survivors, 5 suffer mental retardation.
1967年至1980年期间，在西北大学儿童纪念医院接受治疗的341例儿童脑肿瘤中，有39名儿童（11%）在出生后第一年内发病。我们所治疗的儿童脉络丛乳头状瘤、脑膜肉瘤和畸胎瘤总数的一半发生在这一特定年龄组。幕上肿瘤比幕下肿瘤更常见，比例为1.8:1。髓母细胞瘤和良性星形细胞瘤是最常见的组织学类型。82%的儿童存在脑积水，28%的儿童有视乳头水肿，因此头围进行性增大是转诊的最常见原因。对于37例行肿瘤手术切除或活检的患者，1个月死亡率为19%，1年、3年和5年生存率分别为46%、30%和22%。只要耐受，就给予放射治疗。24例死亡中的大多数发生在诊断后的6个月内。5名患者（分别为1例恶性星形细胞瘤、髓母细胞瘤、脑膜肉瘤，2例脉络丛乳头状瘤）5年后仍存活，无神经或精神缺陷，也无复发迹象。有3例不符合柯林法则。在15名幸存者中，5名患有智力迟钝。
