Scheen A, Juchmès J, Lennes G, Lecomte J
Arch Int Physiol Biochim. 1976 Dec;84(5):915-23. doi: 10.3109/13813457609069454.
VO2 max, maximum oxygen uptake, has been measured in 4 normal young men, before and after beta-adrenergic blockade (0.5 to 5 mg Pindolol by mouth). Pindolol induces bradycardia and reduces VO2 max. A statistically significant positive correlation appears between posology of Pindolol and bradycardia, this posology and reduction of VO2 max, and finally between bradycardia and reduction of VO2 max. These correlations indicate that the reduction of VO2 max is best explained by a circulatory limitation of oxygen supply to active muscles.
对4名正常青年男性在口服β-肾上腺素能阻滞剂（0.5至5毫克吲哚洛尔）前后测量了最大摄氧量（VO2 max）。吲哚洛尔可诱发心动过缓并降低最大摄氧量。吲哚洛尔的剂量与心动过缓、该剂量与最大摄氧量的降低以及最后心动过缓与最大摄氧量的降低之间均呈现出具有统计学意义的正相关。这些相关性表明，最大摄氧量的降低最好用向活动肌肉供氧的循环限制来解释。
