Iványi P, Leupers T, van Mourik P
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4479-83. doi: 10.1073/pnas.80.14.4479.
Human sera contain cytotoxic naturally occurring (CyNa) antibodies which discriminate between lymph node cells from mice differing only at the H-2 complex. Sera from three healthy subjects (normal human sera, NH sera) and one serum from a patient with multiple sclerosis reacted with cells expressing Db, Kd, Kk, and Kp molecules, respectively. However, the following observations suggested that the binding specificity of these CyNa antibodies is to antigens that are distinct from the classical H-2 antigens: (i) the NH sera did not contain cytotoxic anti-HLA antibodies, (ii) redistribution (capping) of H-2 antigens did not induce resistance to lysis for CyNa antibodies, and (iii) individual variation was demonstrated in the expression of the murine lymphocyte antigens detected by the human CyNa antibodies. The reason for this variation appeared to be different for individual NH serum. A maternal effect influenced the expression of the murine lymphocyte antigen detected by one NH serum (anti-H-2b). The differences detected by another NH serum (anti-H-2p) appeared to be inherited, as shown by progeny testing. We hypothesize that the human CyNa antibodies may be directed against antigens controlled or modified by murine viruses (milk borne or endogenous), whose expression is under the influence of the H-2 complex, and that their production might have been stimulated by the products of human genes homologous to murine viruses.
人血清中含有细胞毒性天然存在（CyNa）抗体，这些抗体能够区分仅在H-2复合体上存在差异的小鼠的淋巴结细胞。来自三名健康受试者的血清（正常人血清，NH血清）和一名多发性硬化症患者的血清分别与表达Db、Kd、Kk和Kp分子的细胞发生反应。然而，以下观察结果表明，这些CyNa抗体的结合特异性针对的是与经典H-2抗原不同的抗原：（i）NH血清中不含有细胞毒性抗HLA抗体；（ii）H-2抗原的重新分布（帽化）不会诱导对CyNa抗体裂解的抗性；（iii）人CyNa抗体检测到的小鼠淋巴细胞抗原的表达存在个体差异。这种差异的原因在不同的NH血清中似乎有所不同。一种母体效应影响了一种NH血清（抗H-2b）检测到的小鼠淋巴细胞抗原的表达。另一种NH血清（抗H-2p）检测到的差异似乎是可遗传的，如子代检测所示。我们推测，人CyNa抗体可能针对由鼠病毒（母乳传播或内源性）控制或修饰的抗原，其表达受H-2复合体的影响，并且它们的产生可能受到与鼠病毒同源的人类基因产物的刺激。
