促肾上腺皮质激素释放因子可减少爆发后超极化并兴奋海马神经元。
Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons.
作者信息
Aldenhoff J B, Gruol D L, Rivier J, Vale W, Siggins G R
出版信息
Science. 1983 Aug 26;221(4613):875-7. doi: 10.1126/science.6603658.
PMID:6603658
Abstract
Corticotropin releasing factor in concentrations of 15 to 250 nanomoles per liter increased the spontaneous discharge frequency and decreased the size of hyperpolarizations after burst discharges in CA1 and CA3 pyramidal neurons of rat hippocampal slices. Concentrations greater than 250 nanomoles per liter also depolarized the cells. These excitatory actions of corticotropin releasing factor may involve a novel calcium-dependent process.
摘要
浓度为每升15至250纳摩尔的促肾上腺皮质激素释放因子增加了大鼠海马切片CA1和CA3锥体神经元的自发放电频率，并减小了爆发性放电后的超极化幅度。浓度高于每升250纳摩尔时也会使细胞去极化。促肾上腺皮质激素释放因子的这些兴奋作用可能涉及一个新的钙依赖过程。
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