Traber D L, Jinkins J, Rice K, Sziebert L, Adams T, Henriksen N, Traber L D, Thomson P D
Adv Shock Res. 1983;9:257-63.
The involvement of thymocytes in the cardiopulmonary response to endotoxin was studied in chronically instrumented sheep. Four hours after the administration of 0.75 microgram/kg of endotoxin the blood levels of thymocytes were less than 25% of the control value, at a time when there was a marked fall in the cardiac index and a rise in pulmonary lymph flow. In a second series of experiments sheep were depleted of their thymocytes by the administration of antithymocyte serum. When endotoxin was given to these animals the cardiac output did not fall to the same extent, nor did the hematocrit rise as much as it did in the intact animal. It thus appears that the thymocyte may play a contributing role in the cardiopulmonary response to endotoxin.
在长期植入仪器的绵羊中研究了胸腺细胞对内毒素心肺反应的影响。给予0.75微克/千克内毒素4小时后，胸腺细胞的血液水平低于对照值的25%，此时心脏指数显著下降，肺淋巴流量增加。在第二组实验中，通过给予抗胸腺细胞血清使绵羊的胸腺细胞耗竭。当给这些动物注射内毒素时，心输出量下降的程度没有那么大，血细胞比容升高的幅度也没有完整动物那么大。因此，胸腺细胞似乎可能在内毒素的心肺反应中起一定作用。
