Dechelette E, Batellier H, Seigneurin J M, Beaudoing A
Arch Fr Pediatr. 1983 Mar;40(3):141-7.
Humoral immunity was studied in 40 children presenting with idiopathic nephrotic syndrome (INS), of which 30 with minimal supposed or proven glomerular changes (MGC) and 10 with focal and segmental hyalinosis (FSH). Such patients are capable of producing in vivo active antibodies, in response to viral or bacterial infections and after anti-poliomyelitis immunisation. They present with decreased immunoglobulins G and increased immunoglobulins M during exacerbation of the disease. These abnormalities often persist during remission as well as in patients off-therapy. IgE are often increased during periods or exacerbation as well as in remission. On the contrary, the number of B lymphocytes and their distribution according to surface Ig are normal.
对40例特发性肾病综合征（INS）患儿的体液免疫进行了研究，其中30例有轻微推测或已证实的肾小球改变（MGC），10例有局灶节段性玻璃样变（FSH）。这类患者在受到病毒或细菌感染后以及接种抗脊髓灰质炎疫苗后，能够在体内产生活性抗体。在疾病加重期，他们的免疫球蛋白G降低，免疫球蛋白M升高。这些异常在缓解期以及未接受治疗的患者中也常常持续存在。在疾病加重期以及缓解期，免疫球蛋白E通常都会升高。相反，B淋巴细胞的数量及其根据表面免疫球蛋白的分布是正常的。
