Zúñiga Armendáriz V A, Roberti Riera E, López Monroy A, Gordillo Paniagua G
Bol Med Hosp Infant Mex. 1977 Nov-Dec;34(6):1185-97.
In 78 children with idiopathic nephrotic syndrome, the levels of serum immunoglobulins were studied. In 45 cases with lipoid nephrosis, 7 with segmentary and focal sclerosis and in 26 with membranoproliferative glomerulonephritis, a reduction in per centum values of IgG were found in similar magnitude in the groups. Levels for IgA were not found abnormal and there was an increase in values for IgM exclusively in cases of lipoid nephrosis. There was no difference between disorders shown by cases of active lipoid nephrosis at the beginning or following relapse after some time of evolution. On the other hand it was found that disorders that appeared significantly in magnitude in cases undergoing remission, but specially in those with a greater time of evolution. The difference in these findings with those reported by other authors are attributed to multifactorial causes of lipoid nephrosis and it is supposed that disorders of immunoglobulins represent a functional defect of the lymphocytes T similar to that described as "immunodeficiency linked to chromosome X with high IgM". The association of lipoid nephrosis with certain types of locus HL-A suggest that these immunity alterations might signify a predisposing factor genetically transmitted and suggest the systematic study of these abnormalities in parents and siblings of patients with this disease.
对78例特发性肾病综合征患儿的血清免疫球蛋白水平进行了研究。在45例脂性肾病、7例节段性和局灶性硬化以及26例膜增生性肾小球肾炎患儿中，各组IgG的百分比值均有类似程度的降低。未发现IgA水平异常，仅在脂性肾病患儿中IgM值升高。初发时或病程一段时间后复发的活动性脂性肾病患儿所表现出的病症之间没有差异。另一方面，发现在缓解期的患儿中，尤其是病程较长的患儿中，病症出现的程度明显不同。这些发现与其他作者报道的结果之间的差异归因于脂性肾病的多因素病因，并且推测免疫球蛋白紊乱代表了T淋巴细胞的功能性缺陷，类似于被描述为“与X染色体连锁的高IgM免疫缺陷”。脂性肾病与某些HL - A位点类型的关联表明，这些免疫改变可能意味着一种遗传传递的易感因素，并建议对该病患者的父母和兄弟姐妹的这些异常情况进行系统研究。
