Hepatic changes in a patient with alpha 1-antitrypsin deficiency (MZ phenotype). Portal tract elastosis and noncirrhotic portal hypertension.

A 57-year-old woman with rheumatoid arthritis and alpha 1-antitrypsin deficiency (PiMZ phenotype), recovering from intraabdominal sepsis in association with gastric ulcer perforation, had portal hypertension. An operative liver biopsy specimen showed a distinctive elastosis of the portal tracts without cirrhosis.