Minakata K, Asano M, Mizutani H, Kawashima Y
Clin Biochem. 1983 Apr;16(2):73-5. doi: 10.1016/s0009-9120(83)90304-1.
Variation in alpha-cysteine proteinase inhibitor levels in human sera were investigated with special attention to the effect of pregnancy and diseases. The inhibitor level in 111 pregnant women, examined by our previous method, increased as the pregnancy advanced. The correlation coefficient between the level and the duration, r, was 0.578 with the level of significance p less than 0.001. The mean value for 50 pregnant women in the third trimester of gestation was 0.49 +/- 0.04 unit/mL, which was 47% higher than the control value, 0.33 +/- 0.04 unit/mL (p less than 0.001). However, the levels in patients with myoma of uterus, endometritis, cervical cancer, ovarian cyst and ovarian cancer were not significantly different from the control value. From these results, it was concluded that pregnancy enhanced appreciably the alpha-cysteine proteinase inhibitor level in serum.
研究了人血清中α-半胱氨酸蛋白酶抑制剂水平的变化，特别关注了妊娠和疾病的影响。采用我们之前的方法检测了111名孕妇的抑制剂水平，结果显示随着妊娠进展该水平升高。该水平与妊娠时长的相关系数r为0.578，显著性水平p小于0.001。妊娠晚期50名孕妇的平均值为0.49±0.04单位/毫升，比对照值0.33±0.04单位/毫升高47%（p小于0.001）。然而，子宫肌瘤、子宫内膜炎、宫颈癌、卵巢囊肿和卵巢癌患者的水平与对照值无显著差异。从这些结果得出结论，妊娠显著提高了血清中α-半胱氨酸蛋白酶抑制剂水平。
