Hirasawa H, Odaka M, Soeda K, Kobayashi H, Ohtake Y, Oda S, Kobayashi S, Sato H
Clin Exp Dial Apheresis. 1983;7(1-2):37-47. doi: 10.3109/08860228309076038.
The present study was undertaken to investigate the effect of ATP-MgCl2 on the recovery of renal function following renal ischemia. Bilateral renal ischemia was produced for 90 minutes in dogs. Immediately after the release of ischemia, ATP-MgCl2 (50 mumoles/kg) was given intravenously. Serum creatinine and FeNa were measured following the release of ischemia. Renal cellular energy charge, glomerular endothelial thickness and per cent circularity of interstitial cells were measured. Creatinine and FeNa were significantly lower in ATP-MgCl2 treated dogs compared to those in saline treated controls. Changes in energy charge, glomerular endothelial thickness and per cent circularity indicated ischemically induced renal cellular edema was reversed with ATP-MgCl2 through the improvement of energy metabolism. Taking those experimental data into consideration, ATP-MgCl2 was given to 16 acute renal failure patients and 13 patients survived. ATP-MgCl2 administration is effective for the treatment of acute renal failure.
本研究旨在探讨三磷酸腺苷-氯化镁（ATP-MgCl2）对肾缺血后肾功能恢复的影响。对犬进行双侧肾缺血90分钟。缺血解除后立即静脉给予ATP-MgCl2（50微摩尔/千克）。缺血解除后测定血清肌酐和滤过钠排泄分数（FeNa）。测量肾细胞能荷、肾小球内皮厚度和间质细胞圆形度百分比。与生理盐水处理的对照组相比，ATP-MgCl2处理的犬肌酐和FeNa显著降低。能荷、肾小球内皮厚度和圆形度百分比的变化表明，ATP-MgCl2通过改善能量代谢逆转了缺血诱导的肾细胞水肿。考虑到这些实验数据，对16例急性肾衰竭患者给予ATP-MgCl2，13例患者存活。给予ATP-MgCl2对急性肾衰竭的治疗有效。
