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[抗甲状腺药物治疗对弥漫性毒性甲状腺肿患者各项免疫指标的影响]

[Effect of thyrostatic therapy on various immunologic indices in patients with diffuse toxic goiter].

作者信息

Vnotchenko S L, Starkova N T, Mkrtumova N A

出版信息

Probl Endokrinol (Mosk). 1983 Jul-Aug;29(4):19-23.

PMID:6604271
Abstract

The influence of thyrostatic therapy upon immunoglobulin A, M and G serum concentrations and lymphocytic blast-cell transformation in thyroglobulin and PHA presence in patients with diffuse toxic goiter was studied. The results of the immunological test used do not define quite accurately changes in clinical manifestations of the disease. In the majority of patients disorders of the humoral and/or cell immunity persist during the thyrotoxicosis compensatory stage. A tendency towards normalization or normalization of the parameters studied of T- and B-immune systems is seen under the action of thyrostatic therapy.

摘要

研究了抗甲状腺药物治疗对弥漫性毒性甲状腺肿患者血清免疫球蛋白A、M和G浓度以及在甲状腺球蛋白和植物血凝素存在情况下淋巴细胞母细胞转化的影响。所采用的免疫测试结果并不能十分准确地界定该疾病临床表现的变化。在大多数患者中,体液和/或细胞免疫紊乱在甲状腺毒症代偿期持续存在。在抗甲状腺药物治疗的作用下,可观察到T和B免疫系统所研究参数有趋于正常化或恢复正常的倾向。

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