取代呫吨酮-2-羧酸的合成及某些生物学性质
Synthesis and some biological properties of substituted xanthone-2-carboxylic acids.
作者信息
Eckstein M, Marona H, Mazur J
出版信息
Pol J Pharmacol Pharm. 1983;35(2):159-67.
PMID:6604908
Abstract
Xanthone-2-carboxylic acids 4a-4k were synthesized as potential antiphlogistic compounds, and compounds 4a-4c and 4f-4i were tested for anti-inflammatory and analgesic properties. In the carrageenin paw edema the most potent of the series acid 4b displayed the activity which was approx one third of that of ketoprofen.
摘要
呫吨酮-2-羧酸4a - 4k被合成为潜在的抗炎化合物，并对化合物4a - 4c和4f - 4i进行了抗炎和镇痛特性测试。在角叉菜胶致爪肿胀实验中，该系列中活性最强的酸4b所表现出的活性约为酮洛芬的三分之一。
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