Duncan C C, Lambrecht R M, Rescigno A, Shiue C Y, Bennett G W, Ment L R
Phys Med Biol. 1983 Aug;28(8):963-72. doi: 10.1088/0031-9155/28/8/008.
A prototype instrument based on the coincidence detection of annihilation radiation was built to control the arterial concentration of a radionuclide as a uniformly increasing ramp function over a preset injection interval (ranging from 1.6 min to 13.6 h). The device was designed to accommodate radionuclides of different physical and biological half-life, and the physiological characteristics of the system being studied. A kinetic model based on the Kety-Schmidt integral was developed to permit the determination of cerebral blood flow (CBF). Both the kinetic model and the ramp injector were tested in cats studied with the PETT III positron emission tomograph and 4-(18F)-fluoroantipyrine as the CBF tracer. The ratio lambda/f of the brain-to-blood partition coefficient (lambda) and blood flow (f) were determined simultaneously by serial measurements with positron emission tomography.
构建了一种基于湮灭辐射符合探测的原型仪器，用于在预设的注射间隔（范围从1.6分钟到13.6小时）内将放射性核素的动脉浓度控制为均匀增加的斜坡函数。该装置设计用于适应不同物理和生物半衰期的放射性核素，以及所研究系统的生理特性。开发了一种基于凯蒂 - 施密特积分的动力学模型，以确定脑血流量（CBF）。动力学模型和斜坡注射器均在使用PETT III正电子发射断层扫描仪并以4 - （18F） - 氟安替比林作为CBF示踪剂进行研究的猫身上进行了测试。通过正电子发射断层扫描的系列测量同时确定脑 - 血分配系数（λ）与血流（f）的比率λ/f。
