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Antagonism by tomoxetine of the depletion of norepinephrine and epinephrine in rat brain by alpha-methyl-m-tyrosine.

作者信息

Fuller R W, Hemrick-Luecke S K

出版信息

Res Commun Chem Pathol Pharmacol. 1983 Jul;41(1):169-72.

PMID:6604933
Abstract

Tomoxetine hydrochloride, a potential antidepressant drug, antagonized the alpha-methyl-m-tyrosine-induced depletion of hypothalamic epinephrine and norepinephrine in rats. The findings suggest that tomoxetine, like several uptake-inhibiting antidepressant drugs that have been examined, inhibits uptake into epinephrine neurons as well as norepinephrine neurons in brain.

摘要

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