Hilfiker O, Larsen R, Sonntag H
Br J Anaesth. 1983 Oct;55(10):927-32. doi: 10.1093/bja/55.10.927.
The effects of halothane on myocardial blood flow and myocardial oxygen balance were studied in seven male patients with stable angina and normal left ventricular function. Patients were receiving maintenance doses of beta-receptor antagonists and underwent coronary artery bypass surgery. Anaesthesia consisted of halothane and 50% nitrous oxide in oxygen. Halothane decreased myocardial blood flow and myocardial oxygen consumption by 29% and 32%, respectively, after induction of anaesthesia, and during sternotomy. Myocardial lactate production was not observed at any time. Cardiac index, stroke volume index, mean arterial pressure and mean diastolic arterial pressure were decreased significantly after induction of anaesthesia and during sternotomy. Heart rate remained unchanged. The global myocardial oxygen supply and demand relationship was maintained. The results suggest that halothane is a safe anaesthetic for coronary revascularization in patients with unimpaired left ventricular function.
研究了氟烷对7例稳定型心绞痛且左心室功能正常的男性患者心肌血流和心肌氧平衡的影响。患者接受β受体拮抗剂维持剂量治疗，并接受冠状动脉搭桥手术。麻醉采用氟烷和氧气中50%的氧化亚氮。麻醉诱导后及胸骨切开术期间，氟烷分别使心肌血流和心肌氧耗量降低29%和32%。任何时候均未观察到心肌乳酸生成。麻醉诱导后及胸骨切开术期间，心脏指数、每搏量指数、平均动脉压和平均舒张压均显著降低。心率保持不变。整体心肌氧供需关系得以维持。结果表明，氟烷对于左心室功能未受损的患者进行冠状动脉血运重建术是一种安全的麻醉剂。
