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小鼠脾细胞培养中的自发细胞毒性T细胞。I. 效应细胞和前体细胞的一些特征。

Spontaneous cytotoxic T cells in murine spleen-cell cultures. I. Some characteristics of effector and precursor cells.

作者信息

Ezaki T, Skinner M A, Marbrook J

出版信息

Immunology. 1983 Nov;50(3):343-9.

PMID:6605301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454251/
Abstract

Cytotoxic T cells that arise spontaneously in culture (SCTL) have been characterized using a sensitive plaque reduction (PR) assay. Although SCTL effector cells are highly susceptible to anti-Thy-1 antibody plus complement treatment, they are derived from precursor cells having very low levels of Thy-1 antigen. SCTL are barely detectable in cultures of thymus cells, bone marrow cells, and spleen cells from athymic nu/nu and very old mice. Since SCTL have some similarities to both natural killer cells and normal cytotoxic T cells, SCTL may represent a stage in the T-cell lineage that links these two forms of cytotoxicity.

摘要

利用一种灵敏的蚀斑减少（PR）试验对培养过程中自发产生的细胞毒性T细胞（SCTL）进行了特性鉴定。尽管SCTL效应细胞对抗Thy-1抗体加补体处理高度敏感，但它们来源于Thy-1抗原水平极低的前体细胞。在无胸腺裸鼠和老龄小鼠的胸腺细胞、骨髓细胞及脾细胞培养物中几乎检测不到SCTL。由于SCTL与自然杀伤细胞和正常细胞毒性T细胞均有一些相似之处，SCTL可能代表了T细胞谱系中连接这两种细胞毒性形式的一个阶段。

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引用本文的文献

1
Spontaneous cytotoxic T cells in murine spleen-cell cultures. II. Distinguishing between spontaneous cytotoxic T cells and NK cells according to kinetics and target selectivity.小鼠脾细胞培养中的自发性细胞毒性T细胞。II. 根据动力学和靶标选择性区分自发性细胞毒性T细胞和自然杀伤细胞。
Immunology. 1983 Nov;50(3):351-7.

本文引用的文献

1
Studies on natural killer (NK) cells. III. The effects of in vitro culture on spontaneous cytotoxicity of murine spleen cells.自然杀伤（NK）细胞的研究。III. 体外培养对小鼠脾细胞自发细胞毒性的影响。
J Immunol. 1982 Mar;128(3):1070-5.
2
Spontaneous cytotoxicity.自发细胞毒性
Aust J Exp Biol Med Sci. 1981 Dec;59(Pt 6):681-94. doi: 10.1038/icb.1981.60.
3
Xenogeneic serum-induced mouse T cells that trigger the differentiation of precursor into cytolytic T cells.异种血清诱导的小鼠T细胞，可触发前体细胞分化为细胞毒性T细胞。
J Immunol. 1980 Sep;125(3):1144-51.
4
Functional Thy-1+ cells in cultures of spleen cells from nu/nu mice.裸鼠脾细胞培养物中的功能性 Thy-1+ 细胞。
Eur J Immunol. 1980 Aug;10(8):583-9. doi: 10.1002/eji.1830100803.
5
The haemolytic plaque reduction technique to measure cytotoxicity with hybridoma cells as a target.以杂交瘤细胞为靶标的溶血空斑减少技术用于测量细胞毒性。
J Immunol Methods. 1982 Nov 12;54(3):281-90. doi: 10.1016/0022-1759(82)90312-x.
6
Spontaneous cytotoxic T cells in murine spleen-cell cultures. II. Distinguishing between spontaneous cytotoxic T cells and NK cells according to kinetics and target selectivity.小鼠脾细胞培养中的自发性细胞毒性T细胞。II. 根据动力学和靶标选择性区分自发性细胞毒性T细胞和自然杀伤细胞。
Immunology. 1983 Nov;50(3):351-7.
7
Natural killer cells and their possible relevance to transplantation biology.自然杀伤细胞及其与移植生物学的潜在关联。
Transplantation. 1982 Jul;34(1):1-7.
8
On the heterogeneity of murine natural killer cells.关于小鼠自然杀伤细胞的异质性
J Exp Med. 1981 Sep 1;154(3):750-62. doi: 10.1084/jem.154.3.750.
9
Genetic control of natural cytotoxicity and hybrid resistance.自然细胞毒性和杂种抗性的遗传控制。
Adv Cancer Res. 1980;31:227-85. doi: 10.1016/s0065-230x(08)60659-4.
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Nature. 1976 Oct 21;263(5579):699-701. doi: 10.1038/263699a0.

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