小鼠脾细胞培养中的自发细胞毒性T细胞。I. 效应细胞和前体细胞的一些特征。

Spontaneous cytotoxic T cells in murine spleen-cell cultures. I. Some characteristics of effector and precursor cells.

作者信息

Ezaki T, Skinner M A, Marbrook J

出版信息

Immunology. 1983 Nov;50(3):343-9.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454251/

Abstract

Cytotoxic T cells that arise spontaneously in culture (SCTL) have been characterized using a sensitive plaque reduction (PR) assay. Although SCTL effector cells are highly susceptible to anti-Thy-1 antibody plus complement treatment, they are derived from precursor cells having very low levels of Thy-1 antigen. SCTL are barely detectable in cultures of thymus cells, bone marrow cells, and spleen cells from athymic nu/nu and very old mice. Since SCTL have some similarities to both natural killer cells and normal cytotoxic T cells, SCTL may represent a stage in the T-cell lineage that links these two forms of cytotoxicity.

摘要

利用一种灵敏的蚀斑减少（PR）试验对培养过程中自发产生的细胞毒性T细胞（SCTL）进行了特性鉴定。尽管SCTL效应细胞对抗Thy-1抗体加补体处理高度敏感，但它们来源于Thy-1抗原水平极低的前体细胞。在无胸腺裸鼠和老龄小鼠的胸腺细胞、骨髓细胞及脾细胞培养物中几乎检测不到SCTL。由于SCTL与自然杀伤细胞和正常细胞毒性T细胞均有一些相似之处，SCTL可能代表了T细胞谱系中连接这两种细胞毒性形式的一个阶段。

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引用本文的文献

1

Spontaneous cytotoxic T cells in murine spleen-cell cultures. II. Distinguishing between spontaneous cytotoxic T cells and NK cells according to kinetics and target selectivity.

Immunology. 1983 Nov;50(3):351-7.

本文引用的文献

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