Boxer M I
Neurosci Lett. 1983 Sep 19;40(1):61-5. doi: 10.1016/0304-3940(83)90093-9.
Repeated stimulation can lead to a decrement in the amplitude of a response, or its disappearance. This is known as habituation. Responses recorded in the reticular formation of the brain to peripherally applied stimuli tend to habituate. Decerebration considerably reduces the occurrence of this habituation and naloxone reverses the effect. In decerebrate animals in which such responses rarely habituate, habituation can be induced by administration of D-Ala2,Met5-enkephalinamide and then reversed by a subsequent administration of naloxone. This would suggest that opiates are involved in habituation of responses recorded in the reticular formation of the frog.
重复刺激可导致反应幅度减小或反应消失。这被称为习惯化。记录到的大脑网状结构对周边施加刺激的反应往往会出现习惯化。去大脑状态会显著减少这种习惯化的发生，而纳洛酮可逆转这种效应。在去大脑动物中，此类反应很少出现习惯化，给予D-丙氨酸2、甲硫氨酸5-脑啡肽酰胺可诱导其习惯化，随后给予纳洛酮可使其逆转。这表明阿片类物质参与了青蛙网状结构中记录的反应的习惯化过程。
