通过纤溶酶合成抑制剂对高纤溶状态进行化学控制。
Chemical control of hyperfibrinolytic states by synthetic inhibitors of fibrinolytic enzymes.
作者信息
Markwardt F, Klöcking H P
出版信息
Biomed Biochim Acta. 1983;42(6):725-30.
The effects of two types of synthetic inhibitor of fibrinolytic enzymes (omega-aminocarboxylic acids, benzamidine derivatives) on intravascular fibrinolysis and fibrinogenolysis were studied in rats. Generalised primary fibrinogenolysis was produced by infusion of human plasminogen-streptokinase complex, secondary fibrinolysis was induced by infusion of the thrombin-like enzyme batroxobin. The inhibitors exerted different effects on the hyperfibrinolytic states. The omega-aminocarboxylic acids (PAMBA, AMCA) inhibited fibrinolysis more effective than fibrinogenolysis. In contrast, the benzamidines (APPA, NANP) were more potent inhibitors of fibrinogenolysis. Aprotinin examined for comparison behaved like the benzamidine derivatives.
在大鼠中研究了两种类型的纤维蛋白溶解酶合成抑制剂（ω-氨基羧酸、苯甲脒衍生物）对血管内纤维蛋白溶解和纤维蛋白原溶解的影响。通过输注人纤溶酶原-链激酶复合物产生全身性原发性纤维蛋白原溶解，通过输注类凝血酶巴曲酶诱导继发性纤维蛋白溶解。这些抑制剂对高纤维蛋白溶解状态产生不同影响。ω-氨基羧酸（对氨基甲基苯甲酸、6-氨基己酸）抑制纤维蛋白溶解比抑制纤维蛋白原溶解更有效。相比之下，苯甲脒（4-氨基苯甲脒、N-对氨苯磺酰基-N'-乙酰基-N'-正丙基胍）是更有效的纤维蛋白原溶解抑制剂。作为对照检查的抑肽酶表现得与苯甲脒衍生物相似。
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