患有自然发生免疫缺陷的小鼠中的锥虫病
Trypanosomiasis in mice with naturally occurring immunodeficiencies.
作者信息
Jones J F, Hancock G E
出版信息
Infect Immun. 1983 Nov;42(2):848-51. doi: 10.1128/iai.42.2.848-851.1983.
Abstract
By using mice with naturally occurring defects, we have shown that an intact macrophage system is crucial to survival with the pathogenic protozoan Trypanosoma rhodesiense, since a defect in these cells decreased survival by half. Deficiencies in natural killer cell function or complement levels had no effect on survival. However, the capacity to survive trypanosomiasis was not related to the levels of parasitemia achieved during infection.
摘要
通过使用具有自然发生缺陷的小鼠，我们已经表明，完整的巨噬细胞系统对于感染致病性原生动物罗德西亚锥虫后的存活至关重要，因为这些细胞的缺陷会使存活率降低一半。自然杀伤细胞功能或补体水平的缺陷对存活率没有影响。然而，锥虫病的存活能力与感染期间达到的寄生虫血症水平无关。
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