患有自然发生免疫缺陷的小鼠中的锥虫病
Trypanosomiasis in mice with naturally occurring immunodeficiencies.
作者信息
Jones J F, Hancock G E
出版信息
Infect Immun. 1983 Nov;42(2):848-51. doi: 10.1128/iai.42.2.848-851.1983.
Abstract
By using mice with naturally occurring defects, we have shown that an intact macrophage system is crucial to survival with the pathogenic protozoan Trypanosoma rhodesiense, since a defect in these cells decreased survival by half. Deficiencies in natural killer cell function or complement levels had no effect on survival. However, the capacity to survive trypanosomiasis was not related to the levels of parasitemia achieved during infection.
摘要
通过使用具有自然发生缺陷的小鼠，我们已经表明，完整的巨噬细胞系统对于感染致病性原生动物罗德西亚锥虫后的存活至关重要，因为这些细胞的缺陷会使存活率降低一半。自然杀伤细胞功能或补体水平的缺陷对存活率没有影响。然而，锥虫病的存活能力与感染期间达到的寄生虫血症水平无关。
相似文献
1
Trypanosomiasis in mice with naturally occurring immunodeficiencies.
Infect Immun. 1983 Nov;42(2):848-51. doi: 10.1128/iai.42.2.848-851.1983.
2
Trypanosoma musculi infections in complement-deficient mice.
Exp Parasitol. 1975 Apr;37(2):205-10. doi: 10.1016/0014-4894(75)90071-5.
3
Differences in resistance to Trypanosoma musculi infection among strains of inbred mice.
Infect Immun. 1981 Aug;33(2):364-71. doi: 10.1128/iai.33.2.364-371.1981.
4
Adoptive transfer of variant-specific resistance to Trypanosoma rhodesiense with B lymphocytes and serum.
Infect Immun. 1976 Nov;14(5):1144-50. doi: 10.1128/iai.14.5.1144-1150.1976.
5
Interactions between macrophage cultures infected with Trypanosoma dionisii, lymphocytes and macrophages.
Trans R Soc Trop Med Hyg. 1973;67(2):265-6. doi: 10.1016/0035-9203(73)90171-5.
6
Interaction between murine natural killer cells and trypanosomes of different species.
Infect Immun. 1984 May;44(2):315-9. doi: 10.1128/iai.44.2.315-319.1984.
7
Trypanosoma musculi infection in B-cell-deficient mice.
Infect Immun. 1984 Apr;44(1):162-7. doi: 10.1128/iai.44.1.162-167.1984.
8
Innate control of the early course of infection in mice inoculated with Trypanosoma musculi.
Cell Immunol. 1997 Mar 15;176(2):146-52. doi: 10.1006/cimm.1997.1086.
9
Cell-mediated immunity in nutritional deficiency.
Prog Food Nutr Sci. 1984;8(3-4):193-228.
10
The effect of trypan blue on the early control of Trypanosoma musculi parasitemia in mice.
J Reticuloendothel Soc. 1979 Mar;25(3):325-8.
引用本文的文献
1
Infections With Extracellular Trypanosomes Require Control by Efficient Innate Immune Mechanisms and Can Result in the Destruction of the Mammalian Humoral Immune System.
Front Immunol. 2020 Mar 11;11:382. doi: 10.3389/fimmu.2020.00382. eCollection 2020.
2
Host Immune Responses and Immune Evasion Strategies in African Trypanosomiasis.
Front Immunol. 2019 Nov 22;10:2738. doi: 10.3389/fimmu.2019.02738. eCollection 2019.
3
Trypanosoma rhodesiense: analysis of the genetic control of resistance among mice.
Infect Immun. 1984 Apr;44(1):107-11. doi: 10.1128/iai.44.1.107-111.1984.
4
In vivo analysis of impaired macrophage bactericidal capacity during experimental African trypanosomiasis.
Infect Immun. 1984 Dec;46(3):663-7. doi: 10.1128/iai.46.3.663-667.1984.
5
Genetic resistance to murine cryptococcosis: the beige mutation (Chédiak-Higashi syndrome) in mice.
Infect Immun. 1985 Jan;47(1):288-93. doi: 10.1128/iai.47.1.288-293.1985.
6
Control of trypanodestructive antibody responses and parasitemia in mice infected with Trypanosoma (Duttonella) vivax.
Infect Immun. 1986 Oct;54(1):213-21. doi: 10.1128/iai.54.1.213-221.1986.
7
Identification of an acute-phase reactant in murine infections with Trypanosoma brucei.
Infect Immun. 1992 Sep;60(9):3921-4. doi: 10.1128/iai.60.9.3921-3924.1992.
本文引用的文献
1
2
Dissociation of innate susceptibility to Salmonella infection and endotoxin responsiveness in C3HeB/FeJ mice and other strains in the C3H lineage.
Infect Immun. 1982 May;36(2):696-703. doi: 10.1128/iai.36.2.696-703.1982.
3
4
Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene.
J Immunol. 1980 Jan;124(1):20-4.
5
Defective T-cell response in beige mutant mice.
Nature. 1982 Jan 21;295(5846):240-1. doi: 10.1038/295240a0.
6
7
The CBA/N defect defines two classes of T cell-dependent antigens.
J Immunol. 1981 Apr;126(4):1234-40.
8
Cloning of African trypanosomes in mice immunosuppressed by cyclophosphamide treatment.
Am J Trop Med Hyg. 1982 Nov;31(6):1098-102. doi: 10.4269/ajtmh.1982.31.1098.
9
Non-specific immune responses in CBA/N mice infected with Trypanosoma brucei.
Parasite Immunol. 1981 Autumn;3(3):273-82. doi: 10.1111/j.1365-3024.1981.tb00406.x.
10
Isolation of salivarian trypanosomes from man and other mammals using DEAE-cellulose.
Exp Parasitol. 1970 Dec;28(3):521-34. doi: 10.1016/0014-4894(70)90120-7.
Zotero 插件