C3HeB/FeJ小鼠及C3H系其他品系中沙门氏菌感染先天易感性与内毒素反应性的分离。
Dissociation of innate susceptibility to Salmonella infection and endotoxin responsiveness in C3HeB/FeJ mice and other strains in the C3H lineage.
作者信息
Eisenstein T K, Deakins L W, Killar L, Saluk P H, Sultzer B M
出版信息
Infect Immun. 1982 May;36(2):696-703. doi: 10.1128/iai.36.2.696-703.1982.
Abstract
Studies of various mouse strains in the C3H lineage have shown that there is no correlation between innate susceptibility to Salmonella infection and sensitivity to the toxic or mitogenic effects of lipopolysaccharide (LPS). C3H/HeNCrlBR mice were Salmonella resistant, but sensitive to the toxic and mitogenic effects of LPS, whereas C3HeB/FeJ mice were Salmonella susceptible as the C3H/HeJ mice, yet were mitogenically responsive to LPS and sensitive to its lethal effects. Furthermore, other mouse strains (C3H/HeTex and C3H/HeDub) displayed intermediate susceptibility to Salmonella infection and were responders to the mitogenic and toxic effects of LPS. These results are interpreted to mean that endotoxemia cannot be a major factor in the pathogenesis of Salmonella infection and provide evidence for the involvement of multiple factors in the control of innate resistance to Salmonella infection in mice of the C3H lineage.
摘要
对C3H谱系中各种小鼠品系的研究表明，沙门氏菌感染的先天易感性与对脂多糖（LPS）的毒性或促有丝分裂作用的敏感性之间没有相关性。C3H/HeNCrlBR小鼠对沙门氏菌具有抗性，但对LPS的毒性和促有丝分裂作用敏感，而C3HeB/FeJ小鼠与C3H/HeJ小鼠一样对沙门氏菌易感，但对LPS有促有丝分裂反应且对其致死作用敏感。此外，其他小鼠品系（C3H/HeTex和C3H/HeDub）对沙门氏菌感染表现出中等易感性，并且对LPS的促有丝分裂和毒性作用有反应。这些结果被解释为意味着内毒素血症不可能是沙门氏菌感染发病机制中的主要因素，并为C3H谱系小鼠对沙门氏菌感染的先天抵抗力控制中多种因素的参与提供了证据。
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