Bash J A, Teitelbaum D, Sreevalsan T, Neefe J R
J Biol Response Mod. 1983;2(1):57-65.
Natural killing and antibody-dependent cellular cytotoxicity of peripheral blood lymphocytes from 33 advanced cancer patients were monitored during the course of treatment with human leukocyte interferon in a phase I trial. Ten patients receiving 10 to 60 X 10(6) international units (IU)/m2 in a single injection showed augmentation of cytolytic activity above pretreatment values. The most typical response consisted of a decrease in activity at day 1 followed by a significant increase on day 3 with a return to baseline at day 7. No clearcut minimal immunomodulatory dose was achieved, although four of six patients treated at 60 X 10(6) IU/m6 showed increased activity at day 3. Of these, three subsequently received repeated 60 X 10(6) IU/m2 doses on a weekly basis, and two of these showed repetitive augmentation after 3-4 weeks.
在一项I期试验中，对33例晚期癌症患者外周血淋巴细胞的自然杀伤和抗体依赖性细胞毒性进行了监测，这些患者在接受人白细胞干扰素治疗的过程中。10例单次注射10至60×10⁶国际单位（IU）/m²的患者显示出细胞溶解活性高于治疗前值。最典型的反应是第1天活性下降，随后第3天显著增加，第7天恢复到基线水平。尽管6例接受60×10⁶IU/m²治疗的患者中有4例在第3天显示活性增加，但未明确达到最小免疫调节剂量。其中，3例随后每周重复接受60×10⁶IU/m²剂量，其中2例在3 - 4周后显示出重复性增强。
