Orangio G R, Della Latta P, Marino C, Guarneri J J, Giron J A, Palmer J, Margolis I B
Am J Surg. 1983 Dec;146(6):738-41. doi: 10.1016/0002-9610(83)90330-6.
In our previous study of soft tissue infections in parenteral drug abusers, two thirds of the infections were polymicrobial. Oral and enteric organisms were frequently recovered. These patients and a group of uninfected addicts showed frequent cutaneous anergy, lymphopenia, and hypergammaglobulinemia. An additional group of uninfected addicts was studied. The mean levels of IgA, IgG, and IgM were higher in the uninfected addicts. In the addict and control groups, elevations in IgA (17 percent of total), IgG (65 percent), and IgM (19 percent) levels were found. Zinc levels were within normal limits. T-cell populations below 70 percent were seen in five of the seven addicts and two of the four control subjects. Reversed helper to suppressor cell ratios were found in three of the seven addicts and control subjects. No consistent pattern of immunologic abnormalities emerged. The interrelationship of the abnormalities in the addict and their relationship to AIDS is unclear.
在我们之前关于静脉药物滥用者软组织感染的研究中，三分之二的感染为多微生物感染。口腔和肠道微生物经常被检出。这些患者以及一组未感染的成瘾者经常出现皮肤无反应性、淋巴细胞减少和高球蛋白血症。另外研究了一组未感染的成瘾者。未感染成瘾者的IgA、IgG和IgM平均水平较高。在成瘾者组和对照组中，发现IgA（占总量的17%）、IgG（65%）和IgM（19%）水平升高。锌水平在正常范围内。7名成瘾者中有5名以及4名对照受试者中有2名的T细胞群体低于70%。7名成瘾者和对照受试者中有3名发现辅助性T细胞与抑制性T细胞比例倒置。未出现一致的免疫异常模式。成瘾者中异常情况之间的相互关系及其与艾滋病的关系尚不清楚。
