Kraal G, Weissman I L, Butcher E C
Immunogenetics. 1983;18(6):585-92. doi: 10.1007/BF00345966.
Lyt-2+ T cells constitute a significantly greater proportion of the total peripheral T-cell population in C57BL mice than in BALB/c and other mouse strains. The inheritance of this differential representation of Lyt-2- vs. Lyt-2+ T cells was studied by two-color immunofluorescence analysis of peripheral T cell subsets in BALB/c, C57BL, F1 and F2 generations, and in CXB recombinant inbred strains. It was shown that the C57BL phenotype (low Lyt-2-/Lyt-2+ ratio) is a dominant Mendelian character. Studies of subpopulations of thymocytes and of early thymus emigrants indicate that the representation of mature Lyt-2- and Lyt-2+ T cells is influenced by mechanisms of selection or differential turnover in the peripheral lymphoid organs, but that thymic and prethymic influences may also play a role.
在C57BL小鼠中，Lyt-2+ T细胞在外周血T细胞总数中所占比例显著高于BALB/c及其他小鼠品系。通过对BALB/c、C57BL、F1和F2代以及CXB重组近交系外周血T细胞亚群进行双色免疫荧光分析，研究了Lyt-2-与Lyt-2+ T细胞这种差异表达的遗传情况。结果表明，C57BL表型（低Lyt-2-/Lyt-2+比率）是一种显性孟德尔性状。对胸腺细胞亚群和早期胸腺迁出细胞的研究表明，成熟Lyt-2-和Lyt-2+ T细胞的表达受外周淋巴器官中选择或差异更新机制的影响，但胸腺和胸腺前影响可能也起作用。
