镉暴露小鼠血液和脾脏中淋巴细胞亚群的分布改变。

Modified distribution of lymphocyte subpopulation in blood and spleen from mice exposed to cadmium.

作者信息

Ohsawa M, Sato K, Takahashi K, Ochi T

出版信息

Toxicol Lett. 1983 Oct-Nov;19(1-2):29-35. doi: 10.1016/0378-4274(83)90258-8.

Abstract

The effect of cadmium (Cd) on the lymphocyte subpopulation in peripheral blood and spleen was studied in ICR mice given a daily subcutaneous injection of 0.5 and 1.0 mg Cd/kg body weight for 5 days or mice fed with the drinking water containing 3, 30 and 300 ppm Cd for 10 weeks. The reduction of blood B lymphocytes observed in Cd-injected mice was accompanied by the increase of the number of splenic B lymphocytes. On the other hand in Cd-fed mice the reduction of blood T lymphocytes was found and associated with the increase of the number of splenic T lymphocytes. These findings suggest that circulating lymphocytes may redistribute differentially in lymphoid organs responded to the Cd exposure.

摘要

研究了镉（Cd）对ICR小鼠外周血和脾脏中淋巴细胞亚群的影响。给小鼠每日皮下注射0.5和1.0 mg Cd/kg体重，持续5天；或给小鼠饮用含3、30和300 ppm Cd的饮水，持续10周。在注射镉的小鼠中观察到血液B淋巴细胞减少，同时脾脏B淋巴细胞数量增加。另一方面，在饮用镉水的小鼠中发现血液T淋巴细胞减少，并与脾脏T淋巴细胞数量增加有关。这些发现表明，循环淋巴细胞可能会因镉暴露而在淋巴器官中发生不同的重新分布。