Tomita T, Shimoda Y
Vision Res. 1983;23(11):1309-13. doi: 10.1016/0042-6989(83)90106-2.
The retina in low Cl-media gives rise to spreading depression (SD) accompanied by a large, receptor side negative potential change (SDP). Changes during SD in the membrane potential and the responsiveness to light of various retinal cell types are studied, using a pair of intra- and extracellular electrodes and applying dim white light flashes to the retina at 5 sec intervals throughout the experiment. The study shows that the amacrine and ganglion cells depolarize strongly during SD to complete loss of response to light, and that the start of depolarization in these cell types precedes a little that of SDP. The other cell types continue to respond to light flashes during SD, though their response amplitude decreases as the cells depolarize due probably to an increase in [K+]0 accompanying SD. The results suggest that the amacrine and ganglion cells take an initiative role in the SD generation, and that the changes in the other cell types are mostly of passive nature.
处于低氯培养基中的视网膜会引发扩散性抑制（SD），并伴有一个大的、受体侧负电位变化（SDP）。在整个实验过程中，使用一对细胞内和细胞外电极，并以5秒的间隔向视网膜施加昏暗的白光闪光，研究了SD期间各种视网膜细胞类型的膜电位变化和对光的反应性。研究表明，无长突细胞和神经节细胞在SD期间强烈去极化，直至完全丧失对光的反应，并且这些细胞类型的去极化开始略早于SDP。其他细胞类型在SD期间继续对闪光作出反应，尽管它们的反应幅度随着细胞去极化而减小，这可能是由于SD伴随的[K+]0增加所致。结果表明，无长突细胞和神经节细胞在SD的产生中起主动作用，而其他细胞类型的变化大多是被动性质的。
