Nowak A, Kadyków M, Klimowicz A
Eur J Clin Pharmacol. 1983;25(6):825-7. doi: 10.1007/BF00542528.
In 32 patients the concentrations of sulfamethoxazole and trimethoprim in whole blood, plasma and skin blister fluid were studied in the course of treatment with co-trimoxazole and trimethoprim alone. Measurements were taken on the fourth day of treatment, 3 h after administration of the morning dose of the drug. The blood contained a lower concentration of sulfamethoxazole than plasma. About 70% of the sulfonamide penetrated into the exudate from plasma. Trimethoprim administered conjointly with sulfamethoxazole to a higher degree penetrated skin blister fluid to a greater extent than when given alone.
在32例患者中，研究了复方新诺明和单独使用甲氧苄啶治疗过程中全血、血浆和皮肤水疱液中磺胺甲恶唑和甲氧苄啶的浓度。在治疗的第四天，即上午服用药物3小时后进行测量。血液中磺胺甲恶唑的浓度低于血浆。约70%的磺胺类药物从血浆渗入渗出液。与单独给药相比，与磺胺甲恶唑联合给药时，甲氧苄啶更易渗入皮肤水疱液。
