Pastukhov V A
Fiziol Zh SSSR Im I M Sechenova. 1983 Dec;69(12):1569-74.
In chronic experiments on dogs, the heterogenic effect of serotoninergic structures of the upper and lower parts of the limbic cortex's anterior area was revealed in respect to the heart rate and respiration. Administration of 0.2 mg of serotonin-adipinate (through chemotrodes, bilaterally, in 0.02 ml of saline) into the upper part induced deceleration of the heart rate and respiration whereas the contrary effect occurred after the administration into the lower part. Administration of saline exerted no effect and the i. m. administration of serotonin-adipinate and 5-oxytryptophane (0.5 mg/kg) exerted either no effect as well or a short-lasting one.
在对狗进行的慢性实验中，发现边缘皮质前区上部和下部的血清素能结构对心率和呼吸具有异质性作用。向边缘皮质前区上部双侧通过化学电极注入0.2毫克己二酸血清素（溶于0.02毫升生理盐水中）会导致心率和呼吸减慢，而注入下部则会产生相反的效果。注入生理盐水没有效果，肌肉注射己二酸血清素和5-羟色氨酸（0.5毫克/千克）也没有效果或只有短暂效果。
