Liao Z, Grimshaw R S, Rosenstreich D L
J Exp Med. 1984 Jan 1;159(1):126-36. doi: 10.1084/jem.159.1.126.
The urine of febrile patients has been found to contain high concentrations of an inhibitor of interleukin 1 (IL-1)-induced thymocyte proliferation. The inhibitor is specific for IL-1 and does not block the effects of interleukin 2 (IL-2) or phytohemagglutin (PHA) on thymocytes, and it is not nonspecifically toxic for these cells. IL-1 inhibitor can be found in the urine of normal individuals and afebrile patients, but is present in increased concentrations in the urine of patients with fever of diverse etiologies. Preliminary physicochemical characterization indicates that the inhibitor is a 20-40-kdalton protein.
已发现发热患者的尿液中含有高浓度的白细胞介素1(IL-1)诱导的胸腺细胞增殖抑制剂。该抑制剂对IL-1具有特异性,不会阻断白细胞介素2(IL-2)或植物血凝素(PHA)对胸腺细胞的作用,并且对这些细胞没有非特异性毒性。正常人和无发热患者的尿液中也能发现IL-1抑制剂,但在病因各异的发热患者尿液中其浓度会升高。初步的物理化学特性表明,该抑制剂是一种20 - 40千道尔顿的蛋白质。