在发热患者尿液中鉴定出一种特异性白细胞介素1抑制剂。
Identification of a specific interleukin 1 inhibitor in the urine of febrile patients.
作者信息
Liao Z, Grimshaw R S, Rosenstreich D L
出版信息
J Exp Med. 1984 Jan 1;159(1):126-36. doi: 10.1084/jem.159.1.126.
Abstract
The urine of febrile patients has been found to contain high concentrations of an inhibitor of interleukin 1 (IL-1)-induced thymocyte proliferation. The inhibitor is specific for IL-1 and does not block the effects of interleukin 2 (IL-2) or phytohemagglutin (PHA) on thymocytes, and it is not nonspecifically toxic for these cells. IL-1 inhibitor can be found in the urine of normal individuals and afebrile patients, but is present in increased concentrations in the urine of patients with fever of diverse etiologies. Preliminary physicochemical characterization indicates that the inhibitor is a 20-40-kdalton protein.
摘要
已发现发热患者的尿液中含有高浓度的白细胞介素1（IL-1）诱导的胸腺细胞增殖抑制剂。该抑制剂对IL-1具有特异性，不会阻断白细胞介素2（IL-2）或植物血凝素（PHA）对胸腺细胞的作用，并且对这些细胞没有非特异性毒性。正常人和无发热患者的尿液中也能发现IL-1抑制剂，但在病因各异的发热患者尿液中其浓度会升高。初步的物理化学特性表明，该抑制剂是一种20 - 40千道尔顿的蛋白质。
相似文献
1
Identification of a specific interleukin 1 inhibitor in the urine of febrile patients.在发热患者尿液中鉴定出一种特异性白细胞介素1抑制剂。
J Exp Med. 1984 Jan 1;159(1):126-36. doi: 10.1084/jem.159.1.126.
2
Interleukin 1 activity in normal human urine.正常人尿液中的白细胞介素1活性。
J Immunol. 1984 Jul;133(1):256-60.
3
[An interleukin-1 inhibitor in the urine in febrile patients].
Kansenshogaku Zasshi. 1988 Jun;62(6):539-42. doi: 10.11150/kansenshogakuzasshi1970.62.539.
4
Characterization of a human interleukin 1 inhibitor.
J Immunol. 1985 Jun;134(6):3882-6.
5
6
A urine inhibitor of interleukin 1 activity that blocks ligand binding.一种可阻断配体结合的白细胞介素1活性的尿液抑制剂。
J Immunol. 1987 Sep 1;139(5):1546-9.
7
A novel urinary sialoglycoprotein as the inhibitor of interleukin-1.一种作为白细胞介素-1抑制剂的新型尿唾液糖蛋白。
Clin Exp Immunol. 1989 Jul;77(1):89-96.
8
Uromodulin, an immunosuppressive protein derived from pregnancy urine, is an inhibitor of interleukin 1.尿调节素是一种源自妊娠尿液的免疫抑制蛋白，是白细胞介素1的抑制剂。
Proc Natl Acad Sci U S A. 1986 Dec;83(23):9119-23. doi: 10.1073/pnas.83.23.9119.
9
Human urine deoxyribonuclease increases endogenous thymidine in the mouse thymocyte interleukin 1 assay: an artificial interleukin-1 inhibitor.
Cytokine. 1989 Nov;1(1):52-5. doi: 10.1016/1043-4666(89)91048-x.
引用本文的文献
1
Conservative management of spinal pathology with autologous conditioned serum: A systematic review of the literature.自体条件血清对脊柱病变的保守治疗：文献系统评价
World J Orthop. 2024 Sep 18;15(9):870-881. doi: 10.5312/wjo.v15.i9.870.
2
Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons.小胶质细胞影响肌萎缩侧索硬化症 iPSC 衍生运动神经元中的神经丝沉积。
Genes (Basel). 2022 Jan 27;13(2):241. doi: 10.3390/genes13020241.
3
Evaluation of Tubular Dysfunction Using Urine Biomarkers in Children with COVID-19.使用尿液生物标志物评估新冠病毒感染儿童的肾小管功能障碍
Turk Arch Pediatr. 2022 Jan;57(1):99-103. doi: 10.5152/TurkArchPediatr.2022.21248.
4
Current Therapeutic Options for the Main Monogenic Autoinflammatory Diseases and PFAPA Syndrome: Evidence-Based Approach and Proposal of a Practical Guide.主要单基因自身炎症性疾病和 PFAPA 综合征的当前治疗选择：循证方法和实用指南建议。
Front Immunol. 2020 Jun 3;11:865. doi: 10.3389/fimmu.2020.00865. eCollection 2020.
5
The role of interleukin-1 in general pathology.白细胞介素-1在普通病理学中的作用。
Inflamm Regen. 2019 Jun 6;39:12. doi: 10.1186/s41232-019-0101-5. eCollection 2019.
6
Of Inflammasomes and Alarmins: IL-1β and IL-1α in Kidney Disease.炎症小体与警报素：肾脏疾病中的白细胞介素-1β和白细胞介素-1α
J Am Soc Nephrol. 2016 Sep;27(9):2564-75. doi: 10.1681/ASN.2016020177. Epub 2016 Aug 11.
7
Induction of Myeloid-Derived Suppressor Cells in Cryopyrin-Associated Periodic Syndromes.冷吡啉相关周期性综合征中髓源性抑制细胞的诱导
J Innate Immun. 2016;8(5):493-506. doi: 10.1159/000446615. Epub 2016 Jun 29.
8
Impact of the Type I Interferon Receptor on the Global Gene Expression Program During the Course of Dendritic Cell Maturation Induced by Polyinosinic Polycytidylic Acid.I型干扰素受体对聚肌苷酸胞苷酸诱导的树突状细胞成熟过程中全局基因表达程序的影响。
J Interferon Cytokine Res. 2016 Jun;36(6):382-400. doi: 10.1089/jir.2014.0150. Epub 2016 Apr 1.
9
Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis.I 型干扰素在 T 细胞介导的结肠炎中调节效应器和调节性 T 细胞的积累以及抗炎细胞因子的产生。
J Immunol. 2013 Sep 1;191(5):2771-9. doi: 10.4049/jimmunol.1301093. Epub 2013 Aug 2.
10
Hydrodynamic delivery of chitosan-folate-DNA nanoparticles in rats with adjuvant-induced arthritis.壳聚糖-叶酸-DNA纳米颗粒在佐剂诱导性关节炎大鼠中的流体动力学递送
J Biomed Biotechnol. 2011;2011:148763. doi: 10.1155/2011/148763. Epub 2010 Dec 28.
本文引用的文献
1
Monokine-induced synthesis of serum amyloid A protein by hepatocytes.单核因子诱导肝细胞合成血清淀粉样蛋白A
Nature. 1980 Jun 12;285(5765):498-500. doi: 10.1038/285498a0.
2
Modulation of synovial cell products by a factor from a human cell line: T lymphocyte induction of a mononuclear cell factor.人细胞系因子对滑膜细胞产物的调节作用：单核细胞因子的T淋巴细胞诱导
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5307-11. doi: 10.1073/pnas.79.17.5307.
3
4
Suppression of lymphocyte responses by tuberculous plasma and mycobacterial arabinogalactan. Monocyte dependence and indomethacin reversibility.结核血浆和分枝杆菌阿拉伯半乳聚糖对淋巴细胞反应的抑制作用。单核细胞依赖性和吲哚美辛可逆性。
J Clin Invest. 1981 Jul;68(1):153-62. doi: 10.1172/jci110231.
5
Thymoma production of T cell growth factor (Interleukin 2).胸腺瘤产生T细胞生长因子（白细胞介素2）。
J Immunol. 1980 Dec;125(6):2555-8.
6
The role of alpha 1 protease inhibitor (alpha 1 antitrypsin) in the regulation of immunologic and inflammatory reactions.
Aust N Z J Med. 1980 Aug;10(4):449-53. doi: 10.1111/j.1445-5994.1980.tb04101.x.
7
Macrophage-independent activation of helper T cells. I. Production of Interleukin 2.辅助性T细胞的巨噬细胞非依赖性激活。I. 白细胞介素2的产生
J Immunol. 1980 Aug;125(2):793-8.
8
9
Independent and synergistic thymocyte proliferative activities of PMA and IL 1.佛波酯（PMA）和白细胞介素1（IL-1）独立及协同的胸腺细胞增殖活性
J Immunol. 1982 Sep;129(3):939-41.
10
Demonstration of a circulating suppressor factor of thymocyte proliferation during endotoxin fever in humans.人类内毒素发热期间循环性胸腺细胞增殖抑制因子的证实。
J Immunol. 1981 Dec;127(6):2517-9.
Zotero 插件