Hammarström L, Persson M A, Smith C I
Scand J Immunol. 1983 Dec;18(6):509-13. doi: 10.1111/j.1365-3083.1983.tb00885.x.
Anti-IgA antibodies were found in 14 of 33 (42%) IgA-deficient donors. In healthy IgA-deficient blood donors anti-IgA appeared associated with the presence of HLA DR3. The antibodies were mainly of the IgG1 and, in high-titred sera, IgG4 subclasses. Sera containing high-titred anti-IgA selectively impaired IgA synthesis in vitro as induced by direct and indirect polyclonal B-cell activators. These antibodies may play a role in the pathogenesis and/or the maintenance of IgA deficiency.
在33名IgA缺乏的献血者中，有14名（42%）检测到抗IgA抗体。在健康的IgA缺乏献血者中，抗IgA的出现似乎与HLA DR3的存在有关。这些抗体主要为IgG1，在高滴度血清中则为IgG4亚类。含有高滴度抗IgA的血清在体外可选择性地抑制由直接和间接多克隆B细胞激活剂诱导的IgA合成。这些抗体可能在IgA缺乏的发病机制和/或维持过程中起作用。
