Kern P, Knobloch J, Riethmüller G, Dietrich M
Tropenmed Parasitol. 1983 Dec;34(4):253-8.
Serological investigations (immunoglobulin, haptoglobin, cryoglobulin, and antibody determination against Plasmodium falciparum and P. malariae antigens) were performed in 64 adults of the Albert-Schweitzer-Hospital, Lambarene, Gabon. The patients were referred consecutively for ultrasound examination of the upper abdominal tract. 31 patients had clinically and sonographically an enlarged spleen, whereas 34 had a normal-sized spleen. 18 patients were regarded as having a gross splenomegaly without an obvious underlying cause (tropical splenomegaly (TSS]. No significant differences were seen between the patient groups with regard to immunoglobulin M or antiplasmodial antibody concentration. Thus, a causal association of splenomegaly with chronic malaria infections could not be established. The haptoglobin levels were significantly (P less than 0.01) reduced in patients with splenomegaly. Peripheral T-lymphocyte subsets as defined by monoclonal antibodies showed in all 4 cases with gross splenomegaly examined distinct abnormalities. Tropical splenomegaly is thought to encompass a variety of diseases, most of them presenting an intermediate stage of reactive to autonome disorders of the lymphatic system.
在加蓬兰巴雷内的阿尔贝 - 施韦泽医院对64名成年人进行了血清学调查（免疫球蛋白、触珠蛋白、冷球蛋白以及针对恶性疟原虫和间日疟原虫抗原的抗体测定）。这些患者因上腹部超声检查而被连续转诊。31名患者临床和超声检查显示脾脏肿大，而34名患者脾脏大小正常。18名患者被认为患有无明显潜在病因的巨脾症（热带脾肿大（TSS））。在免疫球蛋白M或抗疟原虫抗体浓度方面，各患者组之间未见显著差异。因此，无法确定脾肿大与慢性疟疾感染之间存在因果关联。脾肿大患者的触珠蛋白水平显著降低（P < 0.01）。通过单克隆抗体定义的外周血T淋巴细胞亚群在所有4例接受检查的巨脾症患者中均显示出明显异常。热带脾肿大被认为涵盖多种疾病，其中大多数呈现出对淋巴系统自主紊乱的反应性中间阶段。
