Heath A R, Basinger S F
Vision Res. 1983;23(12):1371-7. doi: 10.1016/0042-6989(83)90148-7.
To investigate the hypothesis that sugar molecules might act as markers for ROS disc phagocytosis, frog eyecups were incubated in a normally permissive medium for ROS disc shedding with and without added simple sugars. L-fucose, alpha-methyl-D-mannopyranoside and D-mannose all significantly reduced the numbers of packets of ROS discs found in the retinal pigment epithelium. D-fucose, L-mannose, D-fructose, D-galactose, D-glucose and sucrose were without significant effect at the same concentration. Ultrastructural examination of the retinas indicates that the sugars were effective on the disc shedding process rather than on phagocytosis of already shed disc packets.
为了研究糖分子可能作为视网膜外节盘膜吞噬活性氧（ROS）的标志物这一假说，将蛙眼杯分别置于添加和不添加单糖的正常允许ROS外节盘膜脱落的培养基中孵育。L-岩藻糖、α-甲基-D-甘露糖苷和D-甘露糖均显著减少了视网膜色素上皮中ROS外节盘膜的包囊数量。在相同浓度下，D-岩藻糖、L-甘露糖、D-果糖、D-半乳糖、D-葡萄糖和蔗糖没有显著影响。视网膜的超微结构检查表明，这些糖类对盘膜脱落过程有效，而不是对已经脱落的盘膜包囊的吞噬作用有效。
