Jackson E A, Kelly P H
Brain Res Bull. 1983 Nov;11(5):605-11. doi: 10.1016/0361-9230(83)90131-4.
Unilateral injections of dopamine into the substantia nigra pars reticulata of pargyline-pretreated rats caused a prolonged, contralateral circling, similar in magnitude to that elicited by the injection of the same amount of dopamine intrastriatally. Contralateral circling was also elicited by the unilateral intranigral injection of amphetamine (after pargyline pretreatment), or by the dopamine agonists ergometrine and SKF 38393. In contrast, bilateral intranigral injection of the dopamine antagonist haloperidol greatly reduced the amphetamine-induced circling of rats with unilateral 6-hydroxydopamine-induced nigrostriatal lesions. These results support the hypothesis that dopaminergic mechanisms in the substantia nigra are involved in motor behavior.
向用帕吉林预处理的大鼠黑质网状部单侧注射多巴胺，会引起长时间的对侧旋转，其幅度与向纹状体内注射等量多巴胺所引发的相似。向黑质单侧注射苯丙胺（在帕吉林预处理后）、多巴胺激动剂麦角新碱和SKF 38393也会引发对侧旋转。相反，双侧黑质内注射多巴胺拮抗剂氟哌啶醇可大大减少单侧6-羟基多巴胺诱导的黑质纹状体损伤大鼠的苯丙胺诱导的旋转。这些结果支持黑质中的多巴胺能机制参与运动行为的假说。
