24R,25-二羟基维生素D刺激培养的鸡软骨细胞中的肌酸激酶BB活性。
24R,25-dihydroxyvitamin D stimulates creatine kinase BB activity in chick cartilage cells in culture.
作者信息
Sömjen D, Kaye A M, Binderman I
出版信息
FEBS Lett. 1984 Feb 27;167(2):281-4. doi: 10.1016/0014-5793(84)80143-x.
PMID:6607849
Abstract
In chick limb-bud cartilage cell cultures 24R,25-dihydroxycholecalciferol (24R,25(OH)2D3), but not 24S,25(OH)2D3, 1 alpha,25(OH)2D3 or 25(OH)D3, stimulates the activity of the brain type (BB) isozyme of creatine kinase (EC 2.7.3.2), the 'estrogen-induced protein' first identified in rat uterus. Cultures treated with bromodeoxyuridine, in which cartilage formation is inhibited, show no stimulation of creatine kinase BB by 24R,25(OH)2D3.
摘要
在鸡胚肢体芽软骨细胞培养物中，24R,25-二羟胆钙化醇（24R,25(OH)₂D₃）可刺激肌酸激酶（EC 2.7.3.2）脑型（BB）同工酶的活性，而24S,25(OH)₂D₃、1α,25(OH)₂D₃或25(OH)D₃则无此作用，肌酸激酶脑型同工酶是首先在大鼠子宫中发现的“雌激素诱导蛋白”。用溴脱氧尿苷处理的培养物中软骨形成受到抑制，24R,25(OH)₂D₃对肌酸激酶BB无刺激作用。
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