Smith R J, Evans J N
Laryngoscope. 1984 Mar;94(3):395-9. doi: 10.1288/00005537-198403000-00018.
Histiocytosis-X is an uncommon disease, but is relevant to the otolaryngologist because patients with this malady present with, or ultimately develop, head and neck manifestations. Sixty-two patients with histologically confirmed histiocytosis-X have been examined at the Hospital for Sick Children in London since 1958. Most patients were under 2 years of age on initial examination and had either osseous or dermatologic disease involvement. Less commonly, otic or oral lesions were found. Histiocytosis-X is a systemic disease and must be treated accordingly. Isolated lesions may mimic common disease processes, therefore it is imperative that if a seemingly simple problem does not resolve with routine therapy, further patient evaluation be undertaken, If diagnosed, histiocytosis-X can generally be controlled with steroid therapy, or in more recalcitrant cases, by the addition of chemotherapy.
组织细胞增多症-X是一种罕见疾病，但对耳鼻喉科医生来说很重要，因为患有这种疾病的患者会出现或最终发展为头颈部症状。自1958年以来，伦敦大奥蒙德街儿童医院对62例经组织学确诊的组织细胞增多症-X患者进行了检查。大多数患者初次检查时年龄在2岁以下，患有骨病或皮肤病。较少见的情况下，会发现耳部或口腔病变。组织细胞增多症-X是一种全身性疾病，必须进行相应治疗。孤立性病变可能类似于常见疾病过程，因此，如果一个看似简单的问题经常规治疗后没有解决，必须对患者进行进一步评估。如果确诊，组织细胞增多症-X通常可用类固醇治疗控制，或在更顽固的病例中，加用化疗。
