Onsrud M, Kvaløy S
Acta Pathol Microbiol Immunol Scand C. 1984 Feb;92(1):89-91. doi: 10.1111/j.1699-0463.1984.tb00057.x.
The distribution of T lymphocyte subsets was determined in 22 patients with endometrial carcinoma stage 1. Following surgery and postoperative radiotherapy the patients had been "randomized" into two groups: group A patients received no further treatment, whereas group B patients were treated with 17 alpha-hydroxyprogesterone caproate for one year. T cells and T cell subsets were estimated by an indirect immunofluorescence technique using the monoclonal antibodies UCHT3 (mature T cells), OKT4 (T helper cells), and OKT8 (T suppressor/cytotoxic cells). When examined 3-12 months after randomization the two groups had similar numbers of UCHT3+ cells and OKT4+ cells. Group B patients, however, had a significantly lower proportion of OKT8+ cells and hence a significantly higher OKT4/OKT8 ratio than group A patients. It is concluded that progestogen therapy has some immunomodulating effects.
对22例Ⅰ期子宫内膜癌患者的T淋巴细胞亚群分布进行了测定。在手术及术后放疗后，这些患者被“随机”分为两组：A组患者不再接受进一步治疗，而B组患者接受己酸羟孕酮治疗一年。使用单克隆抗体UCHT3（成熟T细胞）、OKT4（辅助性T细胞）和OKT8（抑制性/细胞毒性T细胞），通过间接免疫荧光技术对T细胞及其亚群进行评估。在随机分组后3至12个月进行检查时，两组的UCHT3 +细胞和OKT4 +细胞数量相似。然而，B组患者的OKT8 +细胞比例显著低于A组患者，因此OKT4/OKT8比值显著高于A组患者。结论是孕激素治疗具有一定的免疫调节作用。
