促肾上腺皮质激素释放因子与血管紧张素II：影响神经内分泌和心血管功能的中枢神经系统作用比较

Corticotropin-releasing factor and angiotensin II: comparison of CNS actions to influence neuroendocrine and cardiovascular function.

作者信息

Fisher L A, Brown M R

出版信息

Brain Res. 1984 Mar 26;296(1):41-7. doi: 10.1016/0006-8993(84)90509-2.

Abstract

The cardiovascular and hormonal responses to intracerebroventricular administration of corticotropin-releasing factor (CRF) and angiotensin II (AII) were compared in conscious, freely moving rats. CRF elevated mean arterial pressure (MAP) and heart rate (HR), increased plasma catecholamine levels and had no effect on plasma vasopressin levels. AII increased MAP and decreased HR, had no effect on plasma catecholamine levels and elevated plasma vasopressin levels. Ganglionic blockade with chlorisondamine blocked the cardiovascular effects of CRF but failed to antagonize the pressor response to AII. The vasopressin antagonist, [1-deaminopenicillamine, 2-(0-methyl)tyrosine]-AVP, did not modify CRF-induced cardiovascular changes but greatly attenuated AII's effects on blood pressure. These results suggest that CRF and AII have different central actions on hormonal and cardiovascular systems.

摘要

在清醒、自由活动的大鼠中，比较了脑室内注射促肾上腺皮质激素释放因子（CRF）和血管紧张素II（AII）时的心血管和激素反应。CRF升高平均动脉压（MAP）和心率（HR），增加血浆儿茶酚胺水平，而对血浆血管加压素水平无影响。AII升高MAP并降低HR，对血浆儿茶酚胺水平无影响，但升高血浆血管加压素水平。用氯异吲哚铵进行神经节阻断可阻断CRF的心血管效应，但未能拮抗对AII的升压反应。血管加压素拮抗剂[1-脱氨青霉胺，2-（O-甲基）酪氨酸]-AVP并未改变CRF诱导的心血管变化，但大大减弱了AII对血压的影响。这些结果表明，CRF和AII对激素和心血管系统具有不同的中枢作用。