1-甲基-4-苯基-1,2,3,6-四氢吡啶对猴和人的神经毒性

The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the monkey and man.

作者信息

Burns R S, Markey S P, Phillips J M, Chiueh C C

出版信息

Can J Neurol Sci. 1984 Feb;11(1 Suppl):166-8. doi: 10.1017/s0317167100046345.

Abstract

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) selectively destroys dopaminergic neurons in the pars compacta of the substantia nigra (A8 and A9 cells). MPTP or its metabolite enters nerve cells at the level of their terminals in the caudate nucleus and putamen leading to a disturbance in axoplasmic flow and retrograde degeneration. The species-dependent neurotoxicity of MPTP (primate vs. rodent) suggests that a biochemical property of the cell related to neuromelanin may be important in the mechanism of cell injury.

摘要

1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）选择性破坏黑质致密部的多巴胺能神经元（A8和A9细胞）。MPTP或其代谢产物在尾状核和壳核的神经末梢水平进入神经细胞，导致轴浆流动紊乱和逆行性变性。MPTP的种属依赖性神经毒性（灵长类动物与啮齿动物）表明，与神经黑色素相关的细胞生化特性可能在细胞损伤机制中起重要作用。